Are mixed-breed dogs healthier than purebred dogs? Although they can be, it’s not a guarantee and reputable, good breeding practices make a big difference. Just as a mix could inherit none of the health conditions common to their parent breeds, they could also inherit all of them or some combination of them.
From the English Mastiff side, potential health concerns to be aware of in an English Mastiff Mix include progressive retinal atrophy, hip dysplasia, elbow dysplasia, luxating patella, and cystinuria. Reputable breeders will screen their dogs to avoid passing issues to puppies, so make sure you ask about the health and genetic history of both of the parents.
Because the English Mastiff is one of the dogs breeds at risk for bloat, the same is true for an English Mastiff Mix. The risk may be reduced depending on the other parent breed, but you will still want to be aware of bloat in dogs. The more you know, the more you can reduce the risk and the sooner you can get help if it starts to occur.